Abcam, ab227181, Anti-CTNNA1 antibody

Size: 100µL
Rabbit Polyclonal CTNNA1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Dog, Cat, Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Catenin alpha-1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human, Dog, Cat,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Catenin alpha-1. The exact immunogen used to generate this antibody is proprietary information.P35221

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNA1 also known as alpha-Catenin is an important protein that is involved in cell adhesion. With a molecular weight of about 100 kDa CTNNA1 functions mechanically by linking cadherins which are transmembrane proteins to the actin cytoskeleton in cells. This linkage strengthens cellular junctions and maintains the integrity of tissue architecture. CTNNA1 is widely expressed in epithelial tissues where strong cell-cell adhesion is important for maintaining tissue structure.
Biological function summary
CTNNA1 is important for maintaining cellular integrity and function. It is a part of the adherens junction complex which is critical for the creation of stable cell-cell junctions in tissues. Through the adherens junction it directly associates with E-cadherin and indirectly interacts with the actin cytoskeleton. This structural configuration allows epithelial cells to remain tightly connected facilitating signal transmission between cells for coordinated tissue functioning.
Pathways
CTNNA1 plays a significant role in the Wnt signaling pathway and the regulation of actin dynamics. In the Wnt pathway CTNNA1 is associated with cell fate determination and is known to interact with beta-catenin an important component of this signaling cascade. Additionally by influencing actin cytoskeleton organization CTNNA1 affects cell movement and signal transduction essential for processes like embryogenesis and wound healing.
Disruptions in CTNNA1 function have been linked to cancer and cardiomyopathy. The loss or mutation of CTNNA1 can lead to diminished cell adhesion promoting cancer cell invasion and metastasis often seen in gastric and breast cancers. Moreover its interaction with genes like KIF7 influences cardiomyopathy where structural cardiac tissue changes impair heart function. Understanding CTNNA1's role in these conditions can provide insight for potential therapeutic targets.