Abcam, ab227189, Anti-CARD6 antibody

Size: 100µL
Rabbit Polyclonal CARD6 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CARD6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CARD6. The exact immunogen used to generate this antibody is proprietary information.Q9BX69

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CARD6 also known as Caspase Recruitment Domain-Containing Protein 6 is a protein that weighs approximately 104 kDa. The protein is identified for its involvement in the immune response and connects with microtubules in the cell. It is expressed in various tissues including the heart brain and skeletal muscles. CARD6 contains a CARD (Caspase Activation and Recruitment Domain) enabling it to interact with other proteins containing similar domains.
Biological function summary
CARD6 influences immune system regulation playing a role in apoptosis and inflammation. It does not form a complex with other proteins but instead interacts directly with several proteins through its CARD domain. Notably CARD6 modulates the functions of NF-kB a transcription factor important for immune response regulation and cellular stress responses.
Pathways
CARD6 participates in the NF-kB signaling pathway and the interferon regulatory pathway. These pathways are essential for mediating immune responses and controlling inflammation within the body. CARD6 shows interaction with proteins like RIP2 and TRAF6 within these pathways which further affect the NF-kB signaling cascade.
CARD6 has been linked to Crohn's disease and certain cancers. Abnormalities in its function or expression can lead to dysregulated NF-kB activity contributing to these conditions. CARD6 interacts with proteins such as RIP2 in autoimmune disorders like Crohn's disease and its altered signaling pathway connections can play a role in cancer progression by affecting cell survival and proliferation mechanisms.