Abcam, ab22719, Anti-Cytochrome P450 2B1 + 2B2 antibody [b/e3 (9.14)]

Size: 50µg
Mouse Monoclonal Cytochrome P450 2B1 antibody. Suitable for IP and reacts with Mouse samples. Cited in 4 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:b/e3 (9.14),
Isotype:IgG1,
Carrier free:No,
Reacts with:Mouse,
Applications:IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This product does not react with Rat CYP 1A1, 1A2, 2A1, 2C6, 2C7, 2C11, 4A2 and 4A3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cytochrome P450 2B1 and 2B2 are enzymes that belong to the cytochrome P450 superfamily often referred to as CYP2B1 and CYP2B2 respectively. They are important in drug metabolism and chemical biotransformation. These enzymes have a role in oxidizing organic substances which helps in processing drugs in the liver. Each has a molecular mass of around 54 kDa and shows expression in tissues primarily in the liver and to some extent in the lungs.
Biological function summary
Cytochrome P450 enzymes including 2B1 and 2B2 function to metabolize endogenous and exogenous compounds through monooxygenase activity. 2B1 and 2B2 do not operate in solitude but are involved with the cytochrome P450 complex which includes NADPH-cytochrome P450 reductase. This complex plays an integral role in enabling the metabolism of a wide variety of substrates such as steroids fatty acids and xenobiotics.
Pathways
Cytochrome P450 2B1 and 2B2 take part in the metabolic pathway of xenobiotics and various drugs. These pathways include hydroxylation processes necessary for drug detoxification and clearance. In this context CYP2B1 and CYP2B2 interact closely with other proteins like CYP3A4 which also plays a part in drug metabolism within the liver to ensure coordinated metabolic conversion of foreign chemicals.
CYP2B1 and CYP2B2 have significance in conditions such as liver disease and certain types of drug-induced toxicity. The enzymes' altered activity can lead to improper drug clearance and toxic buildup contributing to liver disorders. They also have associations with specific proteins like GST (glutathione S-transferases) that aid in detoxification and changes in these interactions may exacerbate susceptibility to drug-related liver damage.