Abcam, ab227622, Anti-Lhx4 antibody

Size: 100µL
Rabbit Polyclonal LHX4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LHX4.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LHX4. The exact immunogen used to generate this antibody is proprietary information.Q969G2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Lhx4 also known as LIM homeobox protein 4 serves as a transcription factor characterized by its LIM domain which allows interactions with other proteins. It has a molecular mass of approximately 45 kDa. Expressed mainly in the developing nervous system and certain endocrine tissues Lhx4 plays a role in the regulation of gene expression during developmental stages.
Biological function summary
Lhx4 contributes to neural differentiation and organogenesis by modulating the transcription of specific target genes. It acts as part of a complex with other LIM domain proteins to regulate gene expression patterns. Lhx4’s expression is pivotal for the development of structures such as the pituitary gland and central nervous system influencing cellular differentiation and specialization.
Pathways
The role of Lhx4 extends to several critical biological pathways particularly the Wnt/β-catenin signaling and Hedgehog pathways. Within these Lhx4 interacts with proteins like Lhx3 and β-catenin to help control cellular proliferation and differentiation. Through these pathways Lhx4 plays a role in cell fate decisions ensuring proper development of tissue and organ systems.
Lhx4 has a connection to congenital hypopituitarism and certain neural developmental disorders. Mutations or dysregulation in Lhx4 have associations with pituitary hormone deficits due to its role in pituitary organogenesis. Its interactions with related proteins such as Pit1 and PROP1 which are also involved in pituitary development highlight the importance of Lhx4 in maintaining proper endocrine function.