Abcam, ab227853, Anti-Gbx2 antibody

Size: 100µL
Rabbit Polyclonal GBX2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human GBX2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human GBX2. The exact immunogen used to generate this antibody is proprietary information.P52951

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gbx2 also known as Gastrulation Brain Homeobox 2 functions as a transcription factor. This protein approximately 24 kDa in mass plays a significant role in gene regulation during embryonic development. Gbx2 is expressed mainly in the developing nervous system particularly in the hindbrain and midbrain regions. It influences the expression of other genes critical for brain and cranial nerve development.
Biological function summary
The role of this transcription factor centers on regulating neural development processes. Gbx2 participates in formation and patterning of the central nervous system. It does not typically operate alone; instead it often interacts with other transcription factors to modulate gene expression. Gbx2 is important for demarcating boundaries in the hindbrain which contributes to proper compartmentalization and formation of rhombomeres.
Pathways
Gbx2 contributes significantly to the Wnt and FGF signaling pathways which are fundamental during early neural development stages. In these pathways Gbx2 interacts closely with other key proteins such as Otx2 another homeobox gene to establish clear anterior-posterior axis in the developing brain. These interactions are essential to ensure proper differentiation and positioning of neural cells.
Disruptions in Gbx2 function can lead to neural tube defects and hindbrain malformations. Such abnormalities may associate with disorders like Joubert Syndrome where proper brain segmentation does not occur. Additionally Gbx2's role connects it to the Shh pathway where imbalances might exacerbate conditions like medulloblastoma a type of brain cancer found in children through interactions with proteins such as OTX2.