Abcam, ab228833, Anti-ZNF556 antibody

Size: 100µL
Rabbit Polyclonal ZNF556 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZNF556.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ZNF556. The exact immunogen used to generate this antibody is proprietary information.Q9HAH1

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZNF556 also known as Zinc Finger Protein 556 is a protein characterized by the presence of C2H2-type zinc finger motifs. It has a molecular mass of approximately 76 kDa. Mechanically ZNF556 plays a role in DNA binding and transcriptional regulation. It can bind to specific DNA sequences through its zinc finger domains which function as transcription factors. ZNF556 is expressed in several tissues including brain and liver indicating its potential role in various physiological processes.
Biological function summary
The activity of ZNF556 involves modulation of gene expression and its participation in regulatory networks governing cell growth and differentiation. It functions within a larger complex involving other zinc finger proteins contributing to the regulation of target gene promoters. This interaction emphasizes its importance in maintaining normal cellular processes influencing the expression of genes critical for cell cycle progression and cellular response to external stimuli.
Pathways
ZNF556 is integrated into the MAPK signaling pathway which is significant for its role in cell proliferation and stress response. It also participates in the Wnt signaling pathway influencing cell fate determination and development. Through these pathways ZNF556 interacts with proteins such as MAPK1 and beta-catenin which further illustrates its involvement in cascades that govern cellular homeostasis and development.
ZNF556 has been implicated in certain neurodegenerative diseases such as Alzheimer’s disease due to its expression in brain tissues and its role in transcription regulation. It also relates to liver cancer possibly through dysregulation of the cell cycle and proliferation pathways. In these contexts ZNF556 connects with proteins like tau in Alzheimer’s disease and p53 in liver cancer which are important in understanding the molecular mechanisms underlying these conditions.