Abcam, ab228998, Anti-PYROXD2 antibody

Size: 100µL
Rabbit Polyclonal PYROXD2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PYROXD2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PYROXD2. The exact immunogen used to generate this antibody is proprietary information.Q8N2H3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PYROXD2 also known as Pyridine Nucleotide-Disulfide Oxidoreductase Domain 2 is a protein with a molecular weight of approximately 39 kDa. It functions mechanically as an oxidoreductase enzyme participating in redox reactions by facilitating the transfer of electrons. Expression of PYROXD2 is widespread but shows higher levels in tissues with elevated metabolic activities such as the liver kidney and heart. This widespread expression suggests its fundamental role in cellular processes that require redox homeostasis.
Biological function summary
PYROXD2 contributes to cellular redox balance and detoxification. It operates as part of a larger multi-enzyme complex involved in maintaining oxidative homeostasis in the cell. This function is important for protecting cells against oxidative stress which might lead to cellular damage and apoptosis. By regulating redox-sensitive pathways PYROXD2 helps maintain cellular health and function.
Pathways
PYROXD2 participates in significant biochemical networks focusing on redox regulation and electron transport. Notably the protein interacts within the glutathione metabolic pathway where it works alongside proteins like glutathione peroxidase and glutathione reductase to neutralize reactive oxygen species. PYROXD2 also relates to components of the mitochondrial respiratory chain linking it to important energy-production processes in the cell.
PYROXD2 shows associations with conditions involving oxidative stress including neurodegenerative diseases like Parkinson's Disease. Disrupted redox homeostasis is key in these pathologies where neurons are particularly susceptible to oxidative damage. Additionally PYROXD2 is linked to cardiovascular diseases where oxidative stress contributes to vascular inflammation and damage. These associations point to its potential as a therapeutic target particularly in diseases where oxidative stress plays a critical role.