Abcam, ab229119, Anti-FGFR1OP2 antibody

Size: 100µL
Rabbit Polyclonal FGFR1OP2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FGFR1OP2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FGFR1OP2. The exact immunogen used to generate this antibody is proprietary information.Q9NVK5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FGFR1OP2 protein also known as Fgfr1 Oncogene Partner 2 is a critical component in cellular structural dynamics. It has a molecular mass of approximately 50 kDa. Researchers have identified FGFR1OP2 in different cellular environments including osteoblasts and hematopoietic cells. This presence in diverse tissues suggests a versatile role in cellular processes. The protein participates actively in regulating cytoskeletal integrity and cellular shape reflective of its structural significance.
Biological function summary
FGFR1OP2 interacts with cellular structures and complexes that modulate cytoskeletal components. It helps maintain cellular integrity and facilitate signal transduction processes. FGFR1OP2 can play a part in the centrosome where it aids in maintaining organization and stabilization of microtubules. This role feeds into broader cellular functions like cell division and migration which rely heavily on cytoskeletal adjustments.
Pathways
FGFR1OP2 takes part in cellular processes that involve cytoskeleton-related signaling and reorganization. The protein associates closely with the Ran GTPase pathway which impacts nuclear transport and microtubule organization. FGFR1OP2 also connects with the growth factor receptor (notably FGFR1) signaling pathways. These interactions help manage proliferation signals and cellular structure modifications which are essential during cell cycle events.
FGFR1OP2 shows a relationship with certain types of cancer particularly acute myeloid leukemia (AML) where chromosomal translocations involving FGFR1 can occur. Researchers found that FGFR1OP2 forms fusion proteins which drive aberrant signaling pathways linked to oncogenesis. Another connection between FGFR1OP2 exists in the context of skeletal disorders as its role in osteoblast function may impact bone density and structural anomalies when dysregulated. Through these diseases FGFR1OP2 interacts with proteins like FGFR1 and others involved in cellular growth controls.