Abcam, ab229153, Anti-RCC2 antibody

Size: 100µL
Rabbit Polyclonal RCC2 antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RCC2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RCC2. The exact immunogen used to generate this antibody is proprietary information.Q9P258

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RCC2 also known as TD-60 or Regulator of Chromosome Condensation 2 is a protein involved in cell cycle regulation. It has a mass of approximately 104 kDa. RCC2 is expressed in various tissues with higher levels often observed in proliferating cells. Mechanically RCC2 acts as a regulator of mitosis and contributes to centrosome cohesion and proper chromosomal alignment during cell division by acting as a guanine nucleotide exchange factor (GEF).
Biological function summary
RCC2 plays a role in the coordination of mitotic events. It is part of the chromosomal passenger complex (CPC) which includes other proteins such as Aurora B kinase INCENP and Survivin. These proteins collectively regulate the alignment and segregation of chromosomes during cell division ensuring accurate distribution of genetic material to daughter cells. RCC2's function in this complex helps stabilize the spindle apparatus and ensures timely cytokinesis.
Pathways
RCC2 is significantly involved in cell cycle and mitosis pathways. It interacts closely with proteins such as Aurora B kinase in the regulation of mitotic processes. RCC2 controls the activation of small GTPases which are critical for cellular dynamics during division. Through these interactions RCC2 affects centrosome function and maintenance integrating itself into the broader network of cell cycle regulation.
RCC2 is associated with cancer where its dysregulation may contribute to abnormal cell proliferation. Overexpression or modifications in RCC2 can result in mitotic errors leading to aneuploidy a feature often observed in tumorigenic cells. In particular changes in RCC2 expression levels have been linked to colorectal cancer. It interacts with other proteins like Aurora B kinase in this context exacerbating chromosomal instability and enhancing cancer progression.