Abcam, ab229243, Anti-INTU antibody - C-terminal

Size: 100µL
Rabbit Polyclonal INTU antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human INTU.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human INTU. The exact immunogen used to generate this antibody is proprietary information.Q9ULD6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INTU also known as Intu or Intu sg is an important component in developmental processes. Mechanical functions of this protein involve structural organization and modulation of cellular structures. INTU has a molecular weight of approximately 120 kDa. It displays expression predominantly in epithelial tissues where it plays a role in maintaining tissue morphology by regulating cellular architecture.
Biological function summary
INTU contributes to organizing cilia and managing cytoskeletal arrangement. INTU forms an integral part of the CPLANE complex which is essential for the proper functioning of a variety of cellular components. The activity of INTU in this complex directs ciliary assembly and positioning which are pivotal for signal transduction and cellular responses to environmental stimuli.
Pathways
INTU is an important player in the Hedgehog signaling pathway and planar cell polarity (PCP) pathway. Within the PCP pathway INTU interacts closely with the core PCP proteins which include Vangl2 and Fzd3 to regulate cell orientation and movement. In Hedgehog signaling INTU function is necessary for the transduction of signals that dictate developmental patterning and tissue differentiation across various organisms.
Mutations or malfunctions of INTU have been linked to ciliopathies such as Bardet-Biedl syndrome and neural tube defects. INTU-related anomalies disrupt normal ciliary function impacting ciliogenesis. The protein interacts with other ciliopathy-related proteins like BBS1 and OFD1 influencing ciliogenesis and related cellular processes leading to disease manifestations.