Abcam, ab229254, Anti-FAM120A/OSSA antibody

Size: 100µL
Rabbit Polyclonal FAM120A/OSSA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM120A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FAM120A. The exact immunogen used to generate this antibody is proprietary information.Q9NZB2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAM120A also known as OSSA is a protein that plays a role in cellular signaling. It has a mass of approximately 120 kDa. Researchers observe the expression of this protein in various tissues including testis ovary and brain. FAM120A functions as a scaffolding protein which means it helps organize other proteins at specific locations within cells to facilitate interactions and signaling pathways.
Biological function summary
FAM120A interacts with numerous cellular components and exhibits roles in regulating stress response. It integrates into the RNA granule complex allowing it to influence RNA stability and translation. Through its interaction with the cytoplasmic polyadenylation element-binding proteins it modulates mRNA processing offering insight into how cells manage protein production in response to environmental changes.
Pathways
FAM120A becomes integrated into signaling cascades like the PI3K/Akt pathway. It influences cell survival and growth by modulating interactions with proteins such as Src and Grb2. These interactions contribute to the regulation of key signaling activities that impact various cell functions including proliferation and apoptosis.
FAM120A has connections to cancer and cardiomyopathies. Alterations in its expression or function may affect disease pathogenesis. For instance its relationship with Src contributes to oncogenic signaling pathways influencing cancer progression. In cardiac diseases this protein interacts with pathways that involve binding partners like PI3K where its dysregulation can lead to aberrant heart function or pathology.