Abcam, ab229458, Anti-RPL22 antibody

Size: 100µL
Rabbit Polyclonal RPL22 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human RPL22.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human RPL22.P35268

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RPL22 also known as Ribosomal Protein L22 is a component of the 60S subunit of ribosomes playing an important role in protein synthesis. It has an approximate molecular weight of 16 kDa. Expression of RPL22 occurs in various tissues but it shows high levels in the brain liver and spleen. The protein's structural role within the ribosome allows it to contribute to the assembly and stability necessary for ribosomal function.
Biological function summary
RPL22 contributes to ribosomal biogenesis by being part of a larger ribonucleoprotein complex. It participates in the assembly of the 60S subunit of ribosomes which is essential for translation. The proper function of RPL22 ensures accurate and efficient polypeptide elongation during protein synthesis. Being a part of the ribosomal machinery RPL22 impacts cell proliferation and growth as ribosomes are critical for producing proteins needed for cell development and function.
Pathways
RPL22 plays a role in the translation machinery impacting the protein synthesis pathway. It interacts with other ribosomal proteins such as RPL5 and RPL10 which together facilitate the translation of mRNA into protein. Additionally RPL22 has relevance in the mTOR signaling pathway an important regulator of cell growth and proliferation where it affects processes by influencing ribosomal output and protein translation directly.
RPL22 links to conditions such as cancer and Diamond-Blackfan anemia. Its aberrant expression or mutations can affect ribosome function contributing to tumorigenesis due to uncontrolled protein synthesis and cell proliferation. In particular studies show that leukemia and solid tumors may involve altered RPL22 activity. In Diamond-Blackfan anemia disrupted ribosomal biogenesis due to mutations in RPL22 associates with bone marrow failure. The protein's interactions with other ribosomal proteins like RPS19 help illustrate its potential involvement in these diseases.