Abcam, ab229487, Anti-TAF12 antibody

Size: 100µL
Rabbit Polyclonal TAF12 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TAF12.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TAF12. The exact immunogen used to generate this antibody is proprietary information.Q16514

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TAF12 also known as Transcription initiation factor TFIID subunit 12 is a critical component of the transcription machinery specifically within the TFIID complex. This protein weighs approximately 22 kilodalton and acts as a bridge connecting different proteins within the transcriptional complex. TAF12 shows expression in various tissues with higher levels observed in actively dividing cells like those in the immune system or during embryonic development. Its expression pattern suggests a role in processes that require rapid gene expression changes.
Biological function summary
TAF12 contributes to the formation and stability of the TFIID complex which is essential for the initiation of transcription by RNA polymerase II. As part of this complex TAF12 helps recognize and bind to the core promoter elements of genes facilitating the assembly of the pre-initiation complex. This process drives gene expression that is responsive to various physiological signals. TAF12's interaction with other TAF (TBP-associated factors) proteins ensures precision in the selection of transcription start sites.
Pathways
TAF12 integrates into gene expression pathways affecting cellular proliferation and differentiation. Its role in the canonical Wnt signaling pathway is significant a pathway that regulates important aspects of development and cell signaling. TAF12 also interacts with proteins such as TAF1 and TBP which jointly influence transcription initiation. These protein interactions are fundamental for the regulation of genes that control cell cycle progression and response to external growth signals.
TAF12's function relates closely to cancer and neurodegenerative diseases. Its overexpression or misregulation may lead to oncogenesis as aberrant transcription can drive uncontrolled cell proliferation. In cancers TAF12's interaction with other transcription factors like the ETS family might contribute to tumorigenesis. Additionally alterations in TAF12 might be implicated in neurodegenerative disorders like Alzheimer's disease where the regulation of neuronal gene expression is disrupted. Studies are ongoing to understand fully how TAF12 and its associated proteins influence disease pathology and progression.