Abcam, ab229590, Anti-Neuron specific beta III Tubulin antibody - Neuronal Marker

Size: 100µL
Rabbit Polyclonal Beta-3-tubulin antibody. Suitable for IP, WB, IHC-P, ICC/IF, IHC-Fr and reacts with Human, Mouse, Rat samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human TUBB3.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human, Mouse,
Applications:WB, ICC/IF, IHC-P, IP, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TUBB3. The exact immunogen used to generate this antibody is proprietary information.Q13509

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuron-specific beta III tubulin also known as TUBB3 is a microtubule-associated protein with a molecular mass of approximately 50 kDa. This protein is expressed mostly in neurons but you may also find it in certain non-neuronal cells under specific conditions. As an important component of the cytoskeleton beta III tubulin collaborates with other tubulins to form microtubules essential for maintaining the structural integrity and transport functions within nerve cells.
Biological function summary
Beta III tubulin maintains neuron stability and aids in processes like axonal guidance and dendritic growth. It does not usually form part of a larger complex but interacts dynamically with other microtubule-associated proteins to ensure proper neuron development and function. During neuronal differentiation beta III tubulin is often used as a marker due to its specific expression pattern in neurons compared to other tubulin isoforms.
Pathways
Beta III tubulin plays an important role in the microtubule-based processes that are critical for the neurodevelopmental pathways. It interacts closely with proteins like Tau and MAP2 regulators of microtubule stability. These interactions fall within the larger scope of the axonal transport pathway a major pathway that involves other proteins such as kinesins and dyneins which drive cellular cargoes along the microtubules.
Beta III tubulin mutations relate to conditions like congenital fibrosis of the extraocular muscles (CFEOM) and neurological diseases. These mutations often disturb microtubule dynamics leading to impaired neuronal signaling and transport. The protein interacts with components like kinesin family motor proteins that contribute to axonal transport highlighting its significance in maintaining neural function and its potential in understanding neural-related diseases.