Abcam, ab229630, Anti-FGF-15 antibody

Size: 50µL
Rabbit Polyclonal FGF-15 antibody. Suitable for WB and reacts with Mouse samples. Cited in 17 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Mouse Fgf15.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Mouse Fgf15.O35622

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FGF-15 also known as fibroblast growth factor 15 is a protein with a significant role in various physiological processes. This protein belongs to the fibroblast growth factor (FGF) family and has a molecular mass of approximately 25 kDa. FGF-15 is predominantly expressed in the intestines particularly in the ileum. Its main mechanical function involves the modulation of bile acid synthesis which occurs through its actions on specific receptor targets.
Biological function summary
FGF-15 plays a critical role in liver function and metabolism. It acts as a regulatory factor in bile acid homeostasis and glucose metabolism ensuring the balance and maintenance within the body. FGF-15 does not primarily function as part of a protein complex but it exerts its influence by binding to the fibroblast growth factor receptor 4 (FGFR4) associated with the β-Klotho co-receptor eliciting a signaling cascade important for maintaining metabolic homeostasis.
Pathways
FGF-15 engages in the enterohepatic circulation of bile acids and has a pivotal role in the suppression of bile acid synthesis. One of the key pathways involves fibroblast growth factor receptor signaling pathway. In this capacity FGF-15 works in conjunction with proteins such as FGFR4 and β-Klotho forming a signaling axis that influences the expression of cytochrome P450 family 7 subfamily A member 1 (CYP7A1) an important enzyme in bile acid biosynthesis.
FGF-15 is closely associated with metabolic conditions particularly liver diseases such as non-alcoholic fatty liver disease (NAFLD). Elevated levels of protein expression or dysregulation of its pathway may contribute to the development or progression of such disorders. Additionally abnormalities in the FGF-15 signaling can also impact glucose homeostasis linking it to diabetes. In these contexts FGF-15 works closely with FGFR4 and β-Klotho both important in the therapeutic targeting of these metabolic diseases.