Abcam, ab229679, Anti-Tropomodulin 1 antibody - C-terminal

Size: 100µL
Rabbit Polyclonal Tropomodulin 1 antibody. C-terminal. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TMOD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TMOD1. The exact immunogen used to generate this antibody is proprietary information.P28289

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Tropomodulin 1 also known as TMOD1 is a capping protein responsible for regulating actin filament dynamics by binding to the pointed end of actin filaments preventing filament elongation and depolymerization. This interaction involves actin-binding sites and tropomyosin-binding regions providing stability to the filament structure. Tropomodulin 1 has an approximate mass of 40 kDa and is expressed in multiple tissues predominantly found in skeletal and cardiac muscles where it plays an essential role in maintaining the integrity of muscle fibers.
Biological function summary
Tropomodulin 1 controls the length of actin filaments impacting muscle contraction and cell motility. It forms part of a larger complex with tropomyosin assisting in stabilizing thin filaments. By effectively managing actin filament architecture Tropomodulin 1 contributes to structural cellular functions supporting cell morphology and intracellular transport. Its interaction with tropomyosin facilitates the proper functioning of contractile systems in muscle cells.
Pathways
Tropomodulin 1 participates in the sarcomere organization and muscle contraction pathways where it ensures the appropriate arrangement of the actin cytoskeleton. Tropomodulin 1’s regulation of actin-tropomyosin interactions affects proteins such as troponin which plays an important role in the regulation of calcium binding during muscle contractions. These pathways are critical for muscle development and proper neuromuscular functionality.
Mutations or dysregulation of Tropomodulin 1 have been implicated in cardiomyopathies and nemaline myopathy. These conditions often result from mismanagement of actin filament lengths affecting muscle fiber stability. Tropomodulin 1’s pathological role often involves disruptions in its binding with tropomyosin and such imbalances can lead to severe muscular disorders. By affecting the actin cytoskeleton Tropomodulin 1 connections to proteins such as actin and tropomyosin become significant in understanding these muscle-related diseases.