Abcam, ab229719, Anti-PRELP antibody

Size: 100µL
Rabbit Polyclonal PRELP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PRELP.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PRELP. The exact immunogen used to generate this antibody is proprietary information.P51888

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PRELP also known as proline/arginine-rich end leucine-rich repeat protein is a member of the leucine-rich repeat protein family. It has a molecular weight of approximately 48 kDa. This protein is expressed in connective tissues such as cartilage and tendons. PRELP interacts with many components of the extracellular matrix including biglycan and decorin contributing to the structural organization of these tissues.
Biological function summary
PRELP plays a role in maintaining the integrity of the extracellular matrix by acting as a bridge between fibrous collagens and basement membranes. It is not part of any well-defined complex but its ability to bind to both collagen and basement membrane components is essential for tissue stabilization. PRELP's interaction with heparan sulfate proteoglycans contributes to its function in tissue maintenance and integrity.
Pathways
Some pathways are affected by PRELP's interaction with the extracellular matrix components. PRELP is part of the extracellular matrix organization pathway and can influence collagen fibril formation. Its relationship with fibromodulin and lumican through extracellular interactions suggests its role in the stabilization and assembly of collagen fibrils and overall matrix regulation.
A connection exists between PRELP and conditions involving compromised connective tissues such as osteoarthritis and Ehlers-Danlos syndrome. In these cases altered interaction of PRELP with collagen and extracellular matrix components contributes to disease pathogenesis. The protein's linkage to decorin and fibromodulin further highlights its role in diseases affecting the structural integrity of connective tissues.