Abcam, ab229760, Anti-LAMTOR1 antibody

Size: 100µL
Rabbit Polyclonal LAMTOR1 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human LAMTOR1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human LAMTOR1.Q6IAA8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LAMTOR1 also known as p18 is a protein with a mass of approximately 18 kDa. It functions mechanically as a scaffold protein located on the late endosome/lysosome membrane. The protein's primary role involves recruiting and stabilizing the other members of the Ragulator complex. LAMTOR1 is expressed in various tissues with significant levels in immune and neuronal cells where it supports cellular growth and immune responses.
Biological function summary
LAMTOR1 acts as a part of the highly-conserved Ragulator complex. The Ragulator complex is vital for the activation of the mechanistic target of rapamycin complex 1 (mTORC1) in response to amino acids. LAMTOR1's interaction with other components of the complex such as LAMTOR2 and LAMTOR3 facilitates the localization and activation of mTORC1 on the lysosomal surface. This activation promotes anabolic processes including protein lipid and nucleotide synthesis.
Pathways
LAMTOR1 plays an important role in the mTOR signaling pathway. This pathway regulates cell growth proliferation and metabolism. LAMTOR1's involvement with Rag proteins assists in sensing amino acid levels thereby influencing the mTORC1 pathway activation. Additionally LAMTOR1-related pathways intersect with the AMPK signaling pathway where it functionally interacts with proteins that control cellular energy homeostasis.
LAMTOR1's dysregulation has been associated with conditions like cancer and neurodegenerative disorders. Altered expression of LAMTOR1 can impact mTORC1 signaling leading to uncontrolled cell growth often observed in cancerous cells. In neurodegenerative disorders defects in mTORC1 pathway can cause neuronal cell damage. These conditions link LAMTOR1 to proteins like Rheb and TSC2 which are important for maintaining a balance in these signaling pathways.