Abcam, ab230099, Anti-ZIP-4 antibody

Size: 50µL
Rabbit Polyclonal ZIP-4 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC39A4 aa 1-350.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SLC39A4 aa 1-350. The exact immunogen used to generate this antibody is proprietary information.Q6P5W5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ZIP-4 also known as SLC39A4 functions as a zinc transporter responsible for the uptake of zinc ions from the extracellular space into the cytoplasm. It plays a critical role in maintaining zinc homeostasis within the cell. The protein has a molecular mass of approximately 67 kDa. ZIP-4 is predominantly expressed in the small intestine and pancreas where it regulates zinc absorption important for various biological processes.
Biological function summary
ZIP-4 influences the cellular zinc levels by facilitating zinc influx across the plasma membrane. This transport ensures adequate zinc supply for enzymatic reactions and cellular functions. ZIP-4 does not operate as part of a larger complex but acts independently to regulate zinc entry which impacts cell signaling immune responses and cell proliferation.
Pathways
ZIP-4 participates in the regulation of zinc-dependent pathways such as the MAPK signaling pathway and the NF-kB signaling pathway. These pathways are essential for cell growth survival and immune response. ZIP-4 interacts with other transporters like ZIP-1 and ZIP-10 contributing significantly to the intricate network of zinc homeostasis and cellular regulation.
Abnormal ZIP-4 function has links to acrodermatitis enteropathica a rare genetic disorder caused by impaired zinc absorption. This condition causes skin lesions immune dysfunctions and developmental issues. Additionally dysregulation of ZIP-4 has been implicated in certain cancers where increased ZIP-4 expression correlates with tumor growth and metastasis highlighting its relevance in disease pathology and potential as a therapeutic target.