Abcam, ab230254, Anti-NEDD1 antibody

Size: 50µL
Rabbit Polyclonal NEDD1 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Protein NEDD1 aa 400 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Protein NEDD1 aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NHV4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NEDD1 also known as Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 1 plays a significant mechanical role in the assembly of the gamma-tubulin ring complex. It aids in microtubule nucleation. The protein with a molecular mass of approximately 72 kDa exhibits a strong expression in actively dividing cells particularly in tissues like the brain and testis. NEDD1 serves as an important marker for understanding cell cycle dynamics due to its influence on centrosome and spindle function.
Biological function summary
NEDD1 contributes to the formation and stabilization of microtubule-organizing centers. It is an essential component of the gamma-tubulin ring complex (γ-TuRC) which is integral for the nucleation of microtubules. The localization of NEDD1 to centrosomes influences spindle formation during cell division which is critical for accurate chromosomal segregation. This biological activity highlights the protein’s role in maintaining normal cellular architecture during proliferation.
Pathways
NEDD1 plays key roles in the cell cycle and cellular division pathways. It associates with the gamma-tubulin and other centrosomal proteins like TUBG1 to regulate microtubule formation. During mitosis these interactions ensure precise chromosomal alignment and segregation. In the broader context NEDD1's involvement in these pathways supports cellular roles in growth and response to external stimuli bridging understanding between molecular function and cellular outcomes.
Defects or misregulation in NEDD1 function can lead to conditions like cancer and neurodevelopmental disorders. Aberrant expression or mutation of NEDD1 contributes to centrosome amplification and aneuploidy which are hallmarks of tumorigenesis. In cancer its interaction with proteins like Aurora A kinase influences mitotic spindle assembly errors highlighting its potential as a therapeutic target. Moreover studying its dysfunction in neural tissue provides insights into developmental abnormalities and neurodegenerative diseases.