Abcam, ab230395, Anti-FBXO22 antibody

Size: 50µL
Rabbit Polyclonal FBXO22 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FBXO22 aa 100 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FBXO22 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q8NEZ5

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FBXO22 also known as F-box only protein 22 is a part of the F-box protein family which is involved in protein ubiquitination and degradation. This protein weighs around 35 kDa. It mainly acts as a component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex an important machinery for tagging proteins for proteasomal degradation. FBXO22 expresses ubiquitously in human tissues showing higher levels in areas such as the brain and kidney. The protein's expression patterns suggest its involvement in various cellular processes across different tissues.
Biological function summary
FBXO22 participates in the regulation of the cell cycle and transcription. This protein as part of the SCF complex facilitates the ubiquitination of target substrates which is key in controlling protein turnover. Through its role FBXO22 indirectly influences major cellular functions like DNA replication and repair. The protein often acts alongside SKP1 and CUL1 within this complex contributing to maintaining cellular homeostasis by controlling the levels of specific proteins.
Pathways
FBXO22 plays a notable role in the ubiquitin-proteasome pathway which is essential for protein quality control and removal of misfolded proteins. It also connects to the cell cycle regulatory pathway by influencing the stability of cell cycle regulators. Proteins such as CUL1 and SKP1 interact with FBXO22 during these processes further integrating it into the complex network of proteostasis and cell cycle regulation ensuring the cell's functional integrity.
Studies suggest that FBXO22 is linked to cancer progression especially in breast and prostate cancers. The protein's function in regulating cell cycle proteins and transcription factors may explain this connection as dysregulation can lead to unchecked cell proliferation. A relationship with p53 a tumor suppressor protein has been observed indicating FBXO22's potential impact on tumorigenesis. Additionally alterations in FBXO22 expression or function may influence neurodegenerative conditions where protein accumulation and misfolding are significant factors.