Abcam, ab230445, Anti-EMP-1 antibody - N-terminal

Size: 200µL
Rabbit Polyclonal EMP-1 antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human EMP1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EMP1 aa 1-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P54849

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EMP-1 also known as epithelial membrane protein-1 is a transmembrane protein with a molecular weight of approximately 22 kDa. It is expressed in a variety of tissues including epithelial cells and is highly present in the skin lungs and certain immune cells. EMP-1 belongs to the peripheral myelin protein 22 (PMP22) family sharing structural homology with other tetraspan membrane proteins. The protein serves as a cellular marker for epithelial and some mesenchymal-derived tissues.
Biological function summary
EMP-1 plays a significant role in cell-cell interactions and maintenance of cellular structures. It acts as part of a larger protein complex that contributes to cellular differentiation and tissue integrity. EMP-1 influences cell proliferation and modulates cell morphology which is essential during development and tissue repair. This protein also has a function in signal transduction where it may impact cellular responses to external stress.
Pathways
EMP-1 integrates into multiple signaling pathways such as the MAPK/ERK pathway and the Wnt signaling pathway. These pathways are important for processes like cell growth apoptosis and differentiation. EMP-1 interacts with proteins such as β-catenin and ERK thereby influencing the transcriptional regulation of genes involved in cell survival and growth. The protein’s presence in these pathways highlights its role in cellular physiological adaptations.
EMP-1 has been associated with cancers such as lung cancer and head and neck squamous cell carcinoma. Its expression correlates with tumor progression and metastasis. EMP-1 interacts with proteins like E-cadherin potentially disrupting cell adhesion therefore facilitating cancer cell invasion. Understanding the role of EMP-1 in these diseases could help in developing therapeutic strategies targeting its molecular interactions.