Abcam, ab230645, Anti-WDR48/UAF1 antibody

Size: 200µL
Rabbit Polyclonal WDR48/UAF1 antibody. Suitable for IHC-P, WB, Flow Cyt (Intra) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human WDR48 aa 600-650 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human WDR48 aa 600-650 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q8TAF3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
WDR48 also known as UAF1 is a regulatory subunit that interacts with deubiquitinating enzymes to enhance their activity. It has an approximate molecular mass of 73 kDa. WDR48 contains several WD40 repeats contributing to its role in protein-protein interactions. This protein is expressed in various tissues including the brain liver and kidney indicating its broad physiological relevance.
Biological function summary
The WDR48 protein plays an important role in the regulation of ubiquitin-dependent processes. It functions within the USP1-UAF1 complex which is involved in DNA damage response and repair. WDR48 enhances the deubiquitinating activity of USP1 a process important for maintaining genomic stability. This interaction allows cells to efficiently respond to and repair DNA damage thereby ensuring proper cell cycle progression and survival.
Pathways
WDR48 is integral to the DNA damage repair pathway and the cell cycle regulation pathway. It partners with USP1 and USP12 to mediate deubiquitination processes essential for the repair of DNA lesions. Additionally in the process of DNA repair WDR48 indirectly influences the function of the Fanconi anemia pathway by regulating the stability of components like FANCD2. WDR48's interaction with these proteins demonstrates its involvement in critical cellular functions.
WDR48 has been associated with cancer and neurodegenerative diseases. Its interaction with USP1 is particularly relevant in the context of tumor growth as disruptions in their function may lead to unchecked cell proliferation. Additionally abnormalities in WDR48 function have connections to neurodegenerative disease mechanisms linked through shared pathways with proteins such as ATM an important player in neurological health. These associations highlight the significance of WDR48 in disease mechanisms and make it a potential therapeutic target.