Abcam, ab230709, Anti-CYP4F2 antibody - N-terminal

Size: 50µL
Rabbit Polyclonal CYP4F2 antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 4F2 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Cytochrome P450 4F2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P78329

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP4F2 also known as cytochrome P450 4F2 is an enzyme that catalyzes the metabolism of certain fatty acids and drugs. It possesses a mass of approximately 60 kDa and is primarily expressed in the liver and kidney with noticeable presence in other tissues like the small intestine. This protein plays a role in omega-hydroxylation of fatty acids including arachidonic acid essential for producing signaling molecules called eicosanoids.
Biological function summary
The omega-hydroxylation by CYP4F2 converts fatty acids into hydroxylated derivatives which regulate inflammation and blood pressure. CYP4F2 is not part of a larger complex but interacts with molecular components like heme as a cofactor to carry out its enzymatic functions. Its activity contributes significantly to the body's ability to process and eliminate certain medications and carcinogens.
Pathways
CYP4F2 plays integral roles in the arachidonic acid metabolism pathway and vitamin K-dependent biosynthesis. During these processes CYP4F2 participates alongside related enzymes like CYP2C9 and CYP3A4. In arachidonic acid metabolism it contributes to converting arachidonic acid into 20-hydroxyeicosatetraenoic acid (20-HETE) an active lipid mediator affecting vascular tone.
CYP4F2 has been linked to hypertension and bleeding disorders. Variants in the CYP4F2 gene can affect the enzyme’s ability to metabolize agents involved in blood pressure regulation and warfarin metabolism influencing the risk and management of such conditions. The enzyme’s interaction with cytochrome P450 enzymes including CYP2C9 associated with warfarin metabolism highlights its relevance in pharmacogenetics and personalized medicine.