Abcam, ab230788, Anti-TR1 antibody

Size: 50µg
Rabbit Polyclonal TR1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human TAS1R1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TAS1R1. The exact immunogen used to generate this antibody is proprietary information.Q7RTX1,
Specificity:BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TAS1R2 (69%).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.099% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Thioredoxin reductase 1 (TR1) also known as TXNRD1 is an enzyme that is part of a family of pyridine nucleotide disulfide oxidoreductases. It catalyzes the reduction of thioredoxin using NADPH as an electron donor to maintain cellular redox balance. TR1 is a homodimeric protein with each subunit weighing approximately 55 kDa. It is found expressed in many tissues with higher levels noted in the liver kidney and testis reflecting its diverse cellular roles.
Biological function summary
TR1 influences cellular redox homeostasis and plays a significant role in regulating oxidative stress. It operates as a standalone enzyme not as part of a larger protein complex. By reducing disulfide bonds in proteins it helps to protect cells from oxidative damage and maintains the reduced state of cellular thiols. TR1 also contributes to the regulation of cell proliferation and apoptosis reflecting its multifaceted roles in both normal cellular processes and responses to cellular stress.
Pathways
TR1 takes part in both the oxidative stress response and the regulation of cellular metabolism. It is key within the thioredoxin system pathway working closely with thioredoxin (Trx) to detoxify reactive oxygen species. Additionally TR1 interacts with proteins such as Trx in the regulation of signaling pathways related to apoptosis. Together these interactions facilitate cellular responses to environmental changes.
TR1 displays significant roles in cancer and neurodegenerative diseases. It is frequently overexpressed in various cancer types which can contribute to tumor growth and resistance to therapies. The enzyme also shows connections to neurodegenerative disorders where imbalance in redox regulation and oxidative stress are common pathological features. In both contexts TR1 interacts closely with proteins like thioredoxin further emphasizing its critical place in disease pathogenesis.