Abcam, ab230863, Anti-IFITM5 antibody

Size: 200µL
Rabbit Polyclonal IFITM5 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IFITM5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human IFITM5 aa 50-100 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.A6NNB3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The IFITM5 protein also known by the name BRIL (Bone Restricted Ifitm-Like) is a membrane protein involved in bone development. It has a molecular mass of approximately 16 kDa. Researchers find it primarily expressed in osteoblasts where it plays a role in forming the mineralized matrix. IFITM5 contains two transmembrane domains which allows it to anchor within the smooth endoplasmic reticulum and exert its functions critical to bone health.
Biological function summary
IFITM5 plays an important role in osteoblast differentiation and bone mineralization. It forms part of a cellular framework required for effective bone formation. Through its activity IFITM5 influences deposition and organization of calcium and phosphate two key components for strong bones. As it works within osteoblasts this protein helps regulate processes that ensure proper bone density and structural integrity.
Pathways
IFITM5 interacts within signaling routes that are integral to osteogenesis. It ties in with the Wnt signaling pathway which is essential for bone homeostasis and osteoblast function. Additionally IFITM5 has associations with the LRP5/6 receptor another component in bone regulation pathways. Through these interactions IFITM5 helps modulate signaling events that determine bone growth and turnover.
IFITM5 is closely linked to osteogenesis imperfecta type V a genetic bone disorder characterized by fragile bones prone to fractures. Mutations in the IFITM5 gene result in abnormal bone matrix formation leading to structural deficits. Researchers also study its connection to the COL1A1 and COL1A2 proteins as these proteins share involvement in bone matrix formation and may influence the severity and characteristics of bone disorders.