Abcam, ab230876, Anti-TM2D1/BBP antibody

Size: 50µL
Rabbit Polyclonal TM2D1/BBP antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TM2D1 conjugated to Keyhole Limpet Haemocyanin.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TM2D1 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.Q9BX74

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.3Preservative: 0.01% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TM2D1 protein often called BBP is an important target encoded by the TM2D1 gene. Its molecular weight is approximately 26 kDa. Expression of TM2D1 occurs across several tissues with significant levels noted in the brain. The protein localizes to cellular membranes suggesting involvement in membrane-associated processes. TM2D1 participates in molecular interactions that are essential for proper cellular functioning and signaling.
Biological function summary
TM2D1 is involved in neurodevelopmental processes and cellular communication. It does not function in isolation but as part of a protein complex influencing neurogenesis and synaptic organization. Its actions impact signaling pathways that regulate the development and function of neural tissues. TM2D1's role in these processes points to its significance in maintaining neural integrity and function.
Pathways
TM2D1 interacts in pathways involving proteins like Notch which is essential in neurodevelopment and cellular differentiation. The Notch signaling pathway has a critical influence on cell fate decisions and TM2D1 helps modulate these processes ensuring proper neural development. Another pathway of interest may include those influencing synaptic organization underlining TM2D1's involvement in more specialized neural processes.
TM2D1 has been associated with neurodegenerative conditions such as Alzheimer's disease and Rett syndrome. In Alzheimer's disease TM2D1 may impact amyloid precursor protein processing indirectly linking it to amyloid-beta accumulation. In Rett syndrome a connection might exist with MECP2 another protein involved in neuronal development and function. These associations highlight TM2D1's relevance in neuropathological conditions where its normal function is disrupted leading to disease progression.