Abcam, ab231338, Anti-Intersectin 1 antibody

Size: 100µg
Rabbit Polyclonal Intersectin 1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Rat Itsn1 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Rat Itsn1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q9WVE9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Intersectin 1 also known as ITS1 or intersectin is a multifunctional adaptor protein with a known mass of approximately 180 kDa. It plays a role in clathrin-mediated endocytosis by acting as a scaffold for the organization of various proteins involved in the process. Intersectin 1 is predominantly expressed in the brain but can also be found in other tissues like the heart and kidney. The presence of multiple SH3 domains and DH-PH domains facilitates its interaction with other proteins making it important for synaptic vesicle recycling.
Biological function summary
Intersectin 1 functions as a central hub within signal transduction pathways by forming multimeric complexes. It associates with proteins involved in endocytosis such as dynamin and synaptojanin and coordinates cellular responses to external signals. Its role in actin cytoskeleton dynamics supports its involvement in cell migration and mobility. These functions are essential for normal neurological development and synaptic function.
Pathways
Intersectin 1 integrates into signaling networks primarily within the endocytic and actin cytoskeleton regulatory pathways. It interacts with proteins like Cdc42 and N-WASP contributing to the remodeling of the cytoskeleton. In the receptor-mediated endocytosis pathway intersectin 1 regulates the internalization of membrane receptors influencing cellular communication and maintenance.
Intersectin 1 has connections to neurological and developmental issues including Down syndrome and autism spectrum disorders. This protein's interaction with amyloid precursor protein (APP) suggests a possible link to Alzheimer’s disease through altered APP processing. Additionally intersectin 1's dysregulation can affect pathways related to cell growth and differentiation contributing to cancer progression.