Abcam, ab231526, Anti-PRCP antibody

Size: 100µg
Rabbit Polyclonal PRCP antibody. Suitable for WB, IHC-P and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Mouse Lysosomal Pro-X carboxypeptidase aa 150-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Lysosomal Pro-X carboxypeptidase aa 150-450. The exact immunogen used to generate this antibody is proprietary information.Q7TMR0

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab231526 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PRCP protein also known as Prolylcarboxypeptidase is an enzyme with a molecular weight of around 55 kDa. It functions mechanically by cleaving C-terminal proline residues from peptides. This protein localizes in different tissues including the kidney brain and liver. Its expression is not limited to these areas and can be found in varying levels throughout other tissues in the body.
Biological function summary
PRCP plays a role in several physiological processes including blood pressure regulation and appetite control. It acts as part of a complex involved in degrading peptide hormones like angiotensin II. By modulating these peptide hormones PRCP influences the renin-angiotensin system which is critical for blood pressure homeostasis. The regulation of neuropeptides also impacts the brain's control of appetite and metabolism.
Pathways
PRCP integrates into the renin-angiotensin-aldosterone system (RAAS) and the kallikrein-kinin system. In the RAAS PRCP influences angiotensin II levels which affects vasoconstriction and blood pressure. It has interactions with proteins such as angiotensin-converting enzyme (ACE) within these pathways enhancing its role in vascular biology and fluid balance.
An abnormal activity of PRCP links to hypertension and obesity. Hypertension connects to its activity on the RAAS pathway where it modulates angiotensin II influencing blood vessel constriction. In obesity altered PRCP activity affects neuropeptides in the brain impacting appetite and energy balance. PRCP's modulation of these systems makes it a potential target for therapeutic interventions in these conditions.