Abcam, ab231680, Anti-SAA3 antibody [JOR110A]

Size: 100µg / 1mg
Anti-SAA3 antibody [JOR110A] (ab231680) is a rat monoclonal antibody detecting SAA3 in Western Blot, IHC-P . Suitable for Mouse .
Key facts
Host species:Rat,
Clonality:Monoclonal,
Clone number:JOR110A,
Isotype:IgG2b,
Carrier free:No,
Reacts with:Mouse,
Applications:WB, ICC, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Mouse Saa3 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P04918

Product details:
What is this antibody validated in?
Anti-SAA3 antibody [JOR110A] (ab231680) is a rat monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Mouse samples.
What is the molecular weight of SAA3?
Anti-SAA3 [JOR110A] (ab231680) specifically detects a band for SAA3 (UniProt: P04918) at a molecular weight of 14kDa.
The production method has been switched from hybridoma to recombinant on 24th Oct 2025.
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions--20°C, +4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle, Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Serum Amyloid A3 (SAA3) is a member of the serum amyloid A family of proteins and is known for its acute-phase response activity. This protein has an approximate mass of 14 kDa. SAA3 expression is mainly found in extrahepatic tissues in response to pro-inflammatory stimuli. It increases quickly during inflammation and tissue injury serving as a sensitive marker for inflammatory diseases. SAA3's function in the immune response makes it an important protein for researchers studying inflammation and related conditions.
Biological function summary
SAA3 modulates inflammatory responses and may play a role in the pathogenesis of chronic inflammatory diseases. SAA3 proteins can associate with high-density lipoprotein (HDL) in the bloodstream. Such association changes the lipid metabolism and cholesterol transport affecting the body's inflammatory state. The protein also participates in attracting immune cells like leukocytes to the site of inflammation contributing to immune surveillance and tissue repair.
Pathways
Several studies show that SAA3 participates in the toll-like receptor (TLR) signaling and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways. These pathways are key regulators of the immune response. SAA3 activation can lead to increased cytokine production such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha). Its interactions with other SAAs suggest an overlap in their immune-modulating roles making them important players in systemic inflammation.
SAA3 is linked to conditions like chronic inflammatory diseases and cancer. In rheumatoid arthritis for instance elevated levels of SAA3 correlate with disease severity implicating it as a potential biomarker. The protein is also associated with atherosclerosis where it may influence the development of arterial plaques. Its connection to SAA1 and SAA2 which are also related to inflammation and amyloid deposition highlights a broader role for SAAs in inflammatory and amyloid-related pathologies.