Abcam, ab232430, Anti-Glutamate receptor 3/GluA3 antibody [EP813Y] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Glutamate receptor 3/GluA3 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EP813Y,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:This antibody does not cross-react with Human GRIA1, GRIA2 and GRIA4.

Product details:
ab232430 is the carrier-free version of
ab40845
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Glutamate receptor 3 also known as GluA3 or GRIA3 is an ionotropic receptor that mediates fast excitatory synaptic transmission in the central nervous system. It is part of the AMPA receptor family and has a molecular mass of approximately 100 kDa. This receptor predominantly localizes in the brain where it plays a significant role in the mediation of glutamate neurotransmission influencing synaptic plasticity and communication among neurons. Its expression is vital for transmitting signals across excitatory synapses affecting learning and memory processes.
Biological function summary
GluA3 operates as a subunit of AMPA receptors forming tetrameric complexes that facilitate synaptic signal transmission. These channels permit the influx of sodium and to a lesser extent calcium ions when activated by the neurotransmitter glutamate. The interaction of GluA3 with auxiliary proteins like transmembrane AMPA receptor regulatory proteins (TARPs) can modulate its function and trafficking. As an essential component of synaptic transmission GluA3 influences synaptic strength and is involved in various neuronal activities.
Pathways
GluA3 plays an important role in synaptic plasticity and long-term potentiation (LTP). Two important pathways associated with GluA3 are the mitogen-activated protein kinase (MAPK) pathway and the calcium/calmodulin-dependent protein kinase II (CaMKII) pathway. The regulation of these pathways through GluA3 modulation affects synaptic efficacy and memory formation. GluA3 interacts with proteins like PSD-95 which influences receptor assembly and synapse structure integrating into broader signaling networks that govern cellular responses and adaptations.
GluA3 has been linked to neurodegenerative diseases and psychiatric disorders. Alterations in GluA3 expression or function are associated with Alzheimer's disease where disrupted glutamatergic signaling contributes to cognitive decline. Additionally GluA3 plays a role in schizophrenia where AMPA receptor dysfunction affects neural circuitry and synaptic plasticity. In these contexts GluA3 often interacts with proteins like NMDA receptors where their combined dysfunction can lead to imbalances in excitatory-inhibitory signaling exacerbating disease symptoms.