Abcam, ab23248, Anti-NRG1 type III antibody

Size: 100µg
Rabbit Polyclonal NRG1 antibody. Suitable for WB, IHC-Fr and reacts with Mouse, Rat samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat,
Applications:IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:ab23248 detects ~50-55kDa band in rat sciatic nerve, rat and mouse brain lysate. IHC detection with ab23248 in mouse DRG shows a primarily nuclear localisation of the protein rather than the expected cytoplasmic staining (See Bao and Wang references).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NRG1 type III also known as neuregulin-1 protein is an isoform of the neuregulin-1 protein family. It has a mass of approximately 44 kDa. This protein is expressed mainly in the nervous system including neurons and glial cells and is known to play key roles in nervous system function and development. NRG1 type III facilitates cell signaling by binding to ErbB receptors which are a category of epidermal growth factor receptors.
Biological function summary
This protein variant plays an important role in myelination which is the process of forming a myelin sheath around the nerves. NRG1 type III interacts with the ErbB2 and ErbB3 receptors forming a complex important for these roles. This interaction encourages Schwann cells to initiate and sustain the myelination of peripheral nerves which is vital for proper nerve function and rapid signal transmission.
Pathways
NRG1 type III is actively involved in the PI3K/Akt and MAPK pathways. It interacts with proteins like ErbB2 and ErbB3 to propagate cell growth and survival signals. These pathways influence several cellular processes including cell growth proliferation and survival thereby facilitating communication between neurons and supporting their structural integrity.
NRG1 type III is linked to schizophrenia and Charcot-Marie-Tooth disease. Alterations in NRG1 type III and its pathway components may lead to disrupted neural signaling and connectivity contributing to the pathophysiology of schizophrenia. Furthermore abnormal expression levels of NRG1 type III are associated with Charcot-Marie-Tooth disease a disorder affecting peripheral nerves often in association with changes in the ErbB2 and ErbB3 receptor interaction.