Abcam, ab232624, Anti-GKN2 antibody [EPR15377(B)] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal GKN2 antibody. Carrier free. Suitable for IP, WB, IHC-P and reacts with Human, Mouse, Rat samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR15377(B),
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Rat, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
ab232624 is the carrier-free version of
ab188866
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Gastrokine 2 commonly known as GKN2 is a protein involved in maintaining gastric mucosal integrity. It has an approximate molecular weight of 21 kDa. GKN2 is mainly expressed in the stomach lining particularly in gastric epithelial cells. Alternate names for GKN2 include BRICD1B and CA11ORF18. By contributing to the mucus layer GKN2 helps to protect the underlying tissues from digestive acids and enzymes.
Biological function summary
The role of GKN2 includes important activities within the gastric mucosa. It is known to form part of a protective complex in the stomach that maintains epithelial homeostasis. GKN2 interacts with other gastrokines like GKN1 to support mucosal repair and cell proliferation. It promotes gastric epithelial cell differentiation and inhibits apoptosis which helps control the integrity and function of the stomach lining.
Pathways
GKN2 becomes integral in gastric epithelial cell signaling and repair. It associates closely with pathways related to cell cycle regulation and inflammation control within the gastric environment. GKN1 a related protein often co-regulates these processes alongside GKN2. Their interaction supports gastric healing processes reducing unnecessary cell loss and improving mucosal resilience.
GKN2 shows involvement in gastric cancer and gastritis. Alterations in GKN2 expression can indicate a disruption in gastric mucosal defenses often observed in gastric cancer development. In gastroduodenal disorders like gastritis low levels of GKN2 can correlate with increased inflammation and epithelial damage. GKN1 also shows significant connection to these diseases by interacting with GKN2 to modulate protective mechanisms in the gastric environment.