Abcam, ab232986, Anti-ISLR antibody

Size: 100µg
Rabbit Polyclonal ISLR antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ISLR.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ISLR.O14498

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ISLR also known as Immunoglobulin Superfamily Containing Leucine-rich Repeat is a protein found in various tissues. With a mass of approximately 97 kDa this protein functions mechanically through its involvement in cellular adhesion and signal transduction. ISLR is highly expressed in stromal and immune cell types indicating its role in tissue architecture and immune responses. Its structure includes leucine-rich repeats and immunoglobulin-like domains contributing to its role in cell-cell interaction and communication.
Biological function summary
ISLR participates in critical processes such as cell migration and tissue homeostasis. It is a part of specific protein complexes that mediate interaction with extracellular matrix components and modulate signaling pathways important for immune function. ISLR’s involvement in these complexes suggests it contributes to maintaining the balance between cell proliferation and differentiation which is necessary for proper tissue maintenance. Furthermore its expression pattern highlights its influence on stromal-immune system interactions.
Pathways
ISLR integrates itself into the Wnt signaling pathway and TGF-beta signaling which are fundamental for cellular development and homeostasis. ISLR interacts with other proteins such as beta-catenin and SMADs reflecting its regulatory role in these pathways. These associations point towards its involvement in managing cellular responses to external stimuli and ambiance changes important for cell fate decisions and tissue regeneration.
ISLR shows a strong association with cancer progression and fibrosis. Elevated ISLR expression has been observed in tumor microenvironments implicating its role in promoting an environment conducive to cancer cell survival and proliferation. Additionally the interaction between ISLR and TGF-beta-related proteins can enhance fibrotic responses leading to pathological tissue scarring. Understanding these connections helps in unraveling ISLR's contributions to disease mechanisms potentially presenting targets for therapeutic intervention.