Abcam, ab232995, Anti-LCN1 antibody

Size: 100µg
Rabbit Polyclonal LCN1 antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LCN1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LCN1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P31025

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.011% Proclin 300Constituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LCN1 also known as Lipocalin-1 or tear lipocalin is a secreted protein with a mass of approximately 21 kDa. It primarily localizes in human tears and other secretions including saliva. This protein belongs to the lipocalin family known for their small size and ability to bind hydrophobic molecules. Its key function includes transporting small lipophilic molecules such as fatty acids and retinoids contributing to ocular surface health.
Biological function summary
LCN1 plays an essential role in protecting the eye's surface. It binds and neutralizes bacteria-derived lipopolysaccharides which helps to control microbial growth on the eye surface. LCN1 may interact with other components present in tear film but it does not form a complex with them. The protein participates in transporting molecules across cell membranes and modulating the immune response at ocular and oral sites.
Pathways
LCN1 has a significant role in the defense mechanisms of the tear film. It engages in the immune response pathway helping to maintain homeostasis in the ocular surface microenvironment. Its binding capabilities are related to fatty acid transport pathways. LCN1 indirectly interacts with proteins related to lipid transport such as albumin due to its role in managing lipid interactions at epithelial surfaces.
LCN1 shows a connection to dry eye syndrome a condition resulting from insufficient tear production or quality leading to inflammation and damage to the eye surface. The protein also relates to Sjögren’s syndrome an autoimmune disorder affecting moisture-producing glands. These associations arise because LCN1's deficiency or dysfunction can contribute to the pathology observed in these disorders alongside proteins like lactoferrin which is also important in tear film stability and ocular health.