Abcam, ab233039, Anti-MYPN antibody

Size: 100µg
Rabbit Polyclonal MYPN antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MYPN aa 900 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human, Pig,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MYPN aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q86TC9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab233039 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The MYPN protein also known as myopalladin weighs around 145 kDa. Scientists find MYPN in skeletal and cardiac muscle tissues where it plays a critical role in muscle structure and function. This protein associates with actin filaments and alpha-actinin regulating the organization and stability of the sarcomere the fundamental unit of muscle contraction. By interacting with proteins in the Z-disc MYPN acts as a scaffold which aids in maintaining the architecture necessary for force transmission.
Biological function summary
Myopalladin influences muscle contractility by integrating signals and structural elements in the sarcomere. MYPN forms part of a protein complex involving nebulin and titin which are essential in muscle elasticity and stability. MYPN's presence impacts cellular mechanisms vital in muscle growth and regeneration. It regulates intracellular signaling pathways ensuring muscles respond properly to mechanical stress and maintain their integrity under load.
Pathways
MYPN participates in the MAPK signaling pathway and links with the cytoskeletal regulatory network. In these pathways MYPN works with proteins such as alpha-actinin and titin to mediate cellular responses to mechanical stimuli. These connections highlight its role in maintaining muscle homeostasis. The involvement of MYPN in such pathways signifies its importance in the cellular adaptation process affecting various signal transduction processes and structural developments during muscle contraction and repair.
MYPN mutations associate with conditions like dilated cardiomyopathy and hypertrophic cardiomyopathy. These cardiac diseases show how important MYPN is in maintaining heart muscle function. Mutations can lead to disrupted sarcomere structure causing impaired cardiac function. Additionally the protein connects to titin another sarcomeric protein involved in similar cardiomyopathies highlighting the interplay between sarcomeric proteins in disease mechanisms.