Abcam, ab233229, Anti-SerpinB6/CAP antibody

Size: 100µg
Rabbit Polyclonal SerpinB6/CAP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SERPINB6.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human SERPINB6.P35237

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab233229 was purified by antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SerpinB6 also known as CAP or cytoplasmic antiproteinase functions as a serine protease inhibitor. It weighs approximately 42 kDa. This protein is specific in inhibiting intracellular serine proteases regulating proteolytic processes. SerpinB6 expresses widely across tissues with high levels noted in the extravascular regions such as kidney placenta liver and leukocytes. It serves a cellular protective role by preventing inappropriate proteolysis that could damage cells.
Biological function summary
SerpinB6 plays an important role in protecting cells from protease-dependent damage particularly in stress conditions like heat shock. It operates independently and does not integrate into multiprotein complexes sticking to its role of solo protease control. This protein helps in maintaining cellular integrity safeguarding vital intra-cellular components from degradation by serine proteases particularly during stress responses which affect survival of certain cell types.
Pathways
SerpinB6 contributes significantly to regulating pathways involved in cellular stress response and inflammation. Specifically it engages in pathways such as the regulation of immune response and apoptosis acting alongside other serine protease inhibitors. SerpinB6 interacts with proteins like cathepsin G and elastase which are components of innate immunity and apoptosis pathways.
Dysfunction of SerpinB6 associates with sensorineural hearing loss and certain immune disorders. Hearing loss links to its incapability to inhibit proteases effectively in inner ear cells leading to cell death. In immune disorders inadequate regulation of proteolytic activity can cause exaggerated inflammation. SerpinB6's interaction with proteins such as cathepsin G positions it as a potential therapeutic target for modulating immune responses and preserving auditory function.