Abcam, ab233438, Anti-Raftlin antibody

Size: 100µg
Rabbit Polyclonal Raftlin antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human RFTN1 aa 250-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human RFTN1 aa 250-550. The exact immunogen used to generate this antibody is proprietary information.Q14699

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Antigen-specific affinity chromatography followed by Protein A affinity chromatography., Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 55.77% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Raftlin also known as RFTN1 is an important glycoprotein in cellular mechanics. It has a molecular mass of approximately 180 kDa. Raftlin is broadly expressed in various cell types including immune and epithelial cells. It plays a role mainly in cell membrane components often found in lipid rafts contributing to signal transduction processes.
Biological function summary
Raftlin plays a significant role in immune system functioning. It is important in the formation and stability of lipid rafts specialized membrane microdomains that facilitate efficient signaling. Raftlin associates with the B-cell receptor complex stabilizing complex formation and affecting antibody-mediated immune responses. Through these interactions Raftlin influences the cellular signaling cascade essential for proper immune defense.
Pathways
Raftlin integrates into key immune signaling routes such as the B cell receptor (BCR) signaling pathway. It modulates the recruitment and assembly of signaling molecules influencing pathways like NF-kB essential for immune cell activation. Raftlin interacts with proteins like Lyn and Syk important for signal propagation within these pathways enhancing immune response regulation.
Raftlin is linked to immune-related conditions such as autoimmune diseases. It associates with proteins like CD19 and plays a part in dysregulated BCR signaling which can contribute to pathologies such as lupus. Alterations in Raftlin expression or function can impact immune tolerance and lead to improper immune system activation thereby driving disease processes.