Abcam, ab233806, Anti-PTPRD antibody [5H5D7]

Size: 100µg
Mouse Monoclonal PTPRD antibody. Suitable for Flow Cyt, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050-1300.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:5H5D7,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Receptor-type tyrosine-protein phosphatase delta aa 1050-1300. The exact immunogen used to generate this antibody is proprietary information.P23468

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purified from tissue culture supernatant., Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTPRD also called Protein Tyrosine Phosphatase Receptor Type D functions as a receptor-type protein tyrosine phosphatase. It is an enzyme that removes phosphate groups from tyrosine residues in proteins. This protein has a mass of about 215 kDa and consists of extracellular transmembrane and intracellular regions. It is expressed broadly in human tissues notably in the nervous system and is present in neurons.
Biological function summary
This protein plays a significant role in cell adhesion and signal transduction. It is important for neuronal development as it helps form synaptic connections influencing the communication between neurons. PTPRD forms part of the protein complex involved in cellular signaling pathways regulating processes such as axon guidance and neural patterning. The extracellular regions which interact with cell surface proteins aid in these functions.
Pathways
PTPRD engages in neurodevelopmental and synaptic signaling pathways. It interacts with proteins like LAR (Leukocyte antigen-related) and N-cadherin both involved in neural development. PTPRD’s phosphatase activity alters the phosphorylation status of downstream components integrating into pathways that are critical for neural network formation and function.
PTPRD has been linked to cancer and neurological disorders such as autism spectrum disorder (ASD). Genetic studies have identified that disruptions in the PTPRD gene are associated with increased cancer risk possibly due to its role in cell growth regulation. In neurological contexts PTPRD effects on synaptic connections suggest a connection with ASD where dysfunctions in neural connectivity are common. It shares a pathway relationship with proteins like contactin and TAG-1 which are also implicated in neural development anomalies.