Abcam, ab233939, Anti-smooth muscle Myosin heavy chain I antibody [SMMS-1]

Size: 100µg
Mouse Monoclonal smooth muscle Myosin heavy chain 11 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Tissue preparation containing MYH11 protein.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:SMMS-1,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Tissue preparation containing MYH11 protein. The exact immunogen used to generate this antibody is proprietary information.P35749

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A/G, Purification notes-Purified from bioreactor concentrate by Protein A/G., Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Smooth muscle myosin heavy chain 1 also known as MYH11 plays a significant role in the contractile function of smooth muscle tissues. It is a part of the myosin II family which are motor proteins responsible for converting chemical energy into mechanical force enabling muscle contraction. MYH11 has a high molecular mass approximately 220 kDa and exists primarily in smooth muscles like those in the walls of blood vessels and the gastrointestinal tract.
Biological function summary
MYH11 functions as a critical part of the contractile apparatus in smooth muscle cells. It interacts with actin filaments to initiate contraction utilizing ATP in the process. MYH11 often forms a complex with other proteins including light chains and myosin-binding proteins to ensure proper muscle contraction and relaxation. This complex stabilizes the filament structure optimizing muscle performance.
Pathways
MYH11 integrates into smooth muscle contraction pathways and the cytoskeletal signaling networks. Its activity involves interaction with the RhoA/Rho kinase pathway essential for muscle contraction regulation. Proteins such as actin and tropomyosin work closely with MYH11 in these pathways facilitating coordinated contraction and enabling cells to adapt to mechanical stress.
MYH11 mutations or dysregulation associate with conditions like familial aortic aneurysm and patent ductus arteriosus. In these disorders the normal contractile function of smooth muscle can be compromised leading to vessel weakening. Additionally MYH11 may involve with proteins like actin and caldesmon in these pathologies where altered contractile proteins contribute to disease progression and symptoms.