Abcam, ab23407, Anti-Exendin 4 antibody [20]

Size: 100µg
Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody detecting Exendin 4 in ELISA . - Trusted since 2005
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:20,
Isotype:IgG1,
Light chain type:kappa,
Carrier free:No,
Applications:ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Epitope:The epitope is located in the region of amino acids 9 to 39 of exendin 4.

Product details:
What is this antibody validated in?
Anti-Exendin 4 antibody [20] (ab23407) is a mouse monoclonal antibody and is validated for use in ELISA.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, 2.9% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Exendin-4 also known as "exendine 4" or "exendin e 4" is a peptide with significant activity in glucose metabolism. The peptide originated from the saliva of the Gila monster Heloderma suspectum and has a molecular mass of approximately 4.2 kDa. It is expressed mainly in the pancreas but also found in other tissues. Exendin-4 acts as a potent agonist of the glucagon-like peptide-1 (GLP-1) receptor which is expressed in various parts of the body such as the brain and gastrointestinal tract.
Biological function summary
Exendin-4 enhances insulin secretion helping to regulate blood glucose levels effectively. It mimics the activity of GLP-1 which is involved in stimulating insulin release. Exendin-4 also slows gastric emptying and promotes satiety contributing to reduced food intake. Although the peptide does not form part of a larger complex its interactions directly affect multiple cellular processes relevant to metabolism.
Pathways
Exendin-4 participates in the insulin signaling and glucose homeostasis pathways. It influences insulin receptor substrate proteins thereby playing an important role in maintaining normal blood sugar levels. Exendin-4 modulates the activity of gluconeogenic enzymes connecting it to metabolic pathways involving energy balance and storage.
Exendin-4 shows relevance in treating type 2 diabetes and obesity. By enhancing insulin secretion and reducing appetite it provides therapeutic effects for individuals with diabetes. It shares functional characteristics with proteins like GLP-1 and insulin which are implicated in these metabolic disorders. Research continues to explore its potential benefits and application in managing these conditions more effectively.