Abcam, ab234723, Anti-TBC1D24 antibody

Size: 100µL
Rabbit Polyclonal TBC1D24 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human TBC1D24 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TBC1D24 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9ULP9

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TBC1D24 also known by other names like TRE2-BUB2-CDC16 domain family member 24 functions as a GTPase-activating protein (GAP) for Rab GTPases. Its mass is approximately 66 kDa. This protein is expressed in various tissues including brain and inner ear. It plays a part in the regulation of vesicle trafficking and exocytosis by mediating the hydrolysis of GTP on Rab proteins which is essential for modulating their activity.
Biological function summary
TBC1D24 is involved in the control of neuronal signaling and synaptic function. The protein associates with the synaptic vesicle cycle influencing neurotransmitter release. It is not known to form part of larger protein complexes but it does work closely with other proteins to maintain synaptic efficiency and fidelity. This biological function makes it significant in neural tissue and brain function.
Pathways
TBC1D24 plays a role in processes related to synaptic vesicle trafficking and autophagy. It interacts with components of the Rab family serving as a regulatory factor within these pathways. The protein is linked to Rab35 and other related Rab proteins affecting how cellular materials are transported and recycled ensuring efficient cellular functions.
Mutations in TBC1D24 are connected to epilepsy and nonsyndromic hearing loss. The protein's relation to neural transmission links it to epilepsy where it influences excitatory and inhibitory balances in the brain. Additionally TBC1D24 interacts with several other proteins linked to synaptic function like synapsins indicating its importance in maintaining proper synaptic transmission and preventing neural disorders.