Abcam, ab234744, Anti-YME1L1 antibody

Size: 100µL
Rabbit Polyclonal YME1L1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human YME1L1 aa 1-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human YME1L1 aa 1-250. The exact immunogen used to generate this antibody is proprietary information.Q96TA2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
YME1L1 also known as YME1-like 1 ATPase is a mitochondrial AAA (ATPases Associated with diverse cellular Activities) protease with a molecular mass of approximately 84 kDa. It is mainly expressed in the inner mitochondrial membrane where it functions as an important regulator of mitochondrial protein turnover and quality control. The protein facilitates the degradation of misfolded or damaged polypeptides ensuring mitochondrial integrity and functionality. It also plays a role in the maturation and processing of various mitochondrial components.
Biological function summary
YME1L1 contributes to the maintenance of mitochondrial homeostasis and dynamics. It is a component of the mitochondrial inner membrane complex involved in protein quality control and processing. By mediating the proteolytic degradation of superfluous or defective proteins YME1L1 ensures that the mitochondrial proteome remains balanced and efficient. The protein's activity influences processes like mitochondrial morphology energy production and the regulation of apoptosis highlighting its significance in cellular metabolism and energy balance.
Pathways
YME1L1 is an integral element of mitochondrial protein quality control and respiratory chain regulation. It engages in pathways regulating mitochondrial dynamics interfacing with other mitochondrial proteases and chaperones. The ATP-dependent activity allows it to interact with proteins such as OMA1 and others in the mitochondrial quality control system. Furthermore YME1L1 is involved in mitochondrial metabolism pathways including oxidative phosphorylation where it influences the stability and activity of respiratory chain complexes.
Mutations or dysregulation of YME1L1 have links to neurodegenerative diseases like autosomal dominant optic atrophy (ADOA). Disruption in YME1L1 function can lead to impaired mitochondrial dynamics and bioenergetics contributing to disease progression. The protein shares a connection with OPA1 another key player in mitochondrial dysfunctions associated with ADOA. Additionally abnormalities in YME1L1 have potential implications in metabolic disorders where mitochondrial efficiency is compromised.