Abcam, ab234838, Anti-PTGER3 antibody

Size: 100µg / 100µL
Rabbit Polyclonal PTGER3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human PTGER3 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:ICC/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PTGER3 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.P43115

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The PTGER3 protein also known as the prostaglandin E2 receptor EP3 subtype is a G-protein coupled receptor (GPCR) with a molecular weight of approximately 53 kDa. This receptor binds prostaglandin E2 (PGE2) and modulates various physiological responses by activating different second messenger systems. PTGER3 exhibits diverse expression patterns being present in tissues such as the smooth muscle kidney uterus neural tissues and certain immune cells. Its expression in various tissues suggests its involvement in multiple functions that rely on PGE2 signaling.
Biological function summary
PTGER3 involves itself in mediating the effects of prostaglandin E2 through the inhibition of adenylate cyclase and the modulation of intracellular calcium levels. It does not operate as part of a larger protein complex but functions independently as a receptor. This receptor's activity influences processes such as smooth muscle contraction regulation of body temperature and modulation of hormone release. The variation in signaling allows PTGER3 to have a broad impact on physiological processes adapting its functions based on tissue and cellular context.
Pathways
PTGER3 is part of the prostaglandin signaling pathway and participates in cAMP signaling. It interacts with G-proteins that act as intermediates to modulate adenylate cyclase activity and control cyclic AMP production. The receptor acts in a network with other prostaglandin receptors such as PTGER1 PTGER2 and PTGER4 coordinating responses to PGE2 by either amplifying or opposing their effects depending on the cellular environment. Such interactions position PTGER3 at the junction of pathways critical for homeostatic control and adaptive responses.
PTGER3 has connections to several conditions including inflammatory diseases and hypertension. Inflammatory diseases such as rheumatoid arthritis show altered PGE2 signaling pathways where PTGER3 plays a role in mediating inflammation and immune responses. Its activity is also implicated in regulating blood pressure by influencing vascular smooth muscle contraction. Additionally its function intersects with proteins like COX-2 which is involved in PGE2 biosynthesis indicating a broader role in maintaining homeostasis within disease contexts.