Abcam, ab234876, Anti-LRRTM4 antibody

Size: 100µL
Rabbit Polyclonal LRRTM4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human LRRTM4 aa 250-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human LRRTM4 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.Q86VH4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LRRTM4 also known as Leucine Rich Repeat Transmembrane Neuronal 4 is a protein that plays a critical role in synaptic organization. It is a transmembrane protein mainly found in the postsynaptic density of excitatory synapses. LRRTM4 has a molecular mass of approximately 65 kDa. It is highly expressed in the brain particularly in regions involved in cognitive functions such as the hippocampus and cortex.
Biological function summary
The protein facilitates synapse development and maintenance influencing synaptic transmission by interacting with presynaptic partners. LRRTM4 acts as a synaptic organizer and is part of the postsynaptic membrane complex. It works closely with other synaptic proteins to facilitate synaptogenesis and maintain synaptic plasticity essential for learning and memory processes.
Pathways
LRRTM4 operates within neural communication pathways critical for synaptic development. It interacts with neurexins which are essential to the presynaptic organization forming complexes that aid neurotransmitter release. Furthermore it is involved in the organization of excitatory synapse pathways similar to its relative protein LRRTM2 which also shares a role in excitatory synaptic function.
The dysregulation of LRRTM4 expression has been linked to neurodevelopmental disorders such as autism spectrum disorders (ASD) and schizophrenia. Aberrant expression or function of LRRTM4 can contribute to the synaptic deficits observed in these conditions. The protein is associated with synaptic proteins like neuroligins which are implicated in similar neurodevelopmental disorders further emphasizing its importance in maintaining synaptic health.