Abcam, ab235300, Anti-FAPP2 antibody

Size: 100µL
Rabbit Polyclonal FAPP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLEKHA8 aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human PLEKHA8 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q96JA3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
FAPP2 also known as Four-phosphate adaptor protein 2 is an important protein involved in lipid binding and transport. It has a molecular mass of approximately 56 kDa. This protein predominantly localizes in the Golgi apparatus within cells. Its presence is especially prominent in tissues with high levels of secretory activity. FAPP2 functions through its PtdIns(4)P binding capability which facilitates its role in the secretory pathway allowing the transport of glucosylceramide.
Biological function summary
The actions of FAPP2 include the facilitation of lipid transfer and membrane trafficking. It interacts with specific membrane lipids aiding in the formation of transport carriers essential for lipid delivery and glycosphingolipid synthesis. FAPP2 operates within a complex network involving other proteins to ensure accurate lipid sorting and delivery. Its precise role in orchestrating these cellular activities highlights its significance in maintaining membrane composition and signaling.
Pathways
FAPP2 integrates within critical lipid-related processes including the glycosphingolipid biosynthesis and Golgi membrane trafficking pathways. In the glycosphingolipid biosynthesis FAPP2 connects with glucosylceramide and other lipids orchestrating their transport to appropriate cellular destinations. Additionally FAPP2 shares interactions with proteins like CERT and OSBP which are involved in lipid homeostasis and intracellular transport cementing its place as a mediator of critical lipid dynamics.
FAPP2 has associations with disorders related to lipid metabolism such as Gaucher's disease and other lysosomal storage disorders. In these disorders anomalies in lipid transport and metabolism can exacerbate symptoms due to dysfunctional glycosphingolipid synthesis pathways. FAPP2's interactions with proteins like glucosylceramide synthase further illustrate its involvement in disease mechanisms providing a potential target for therapeutic interventions.