Abcam, ab235919, Anti-S1PR2 antibody

Size: 100µL
Rabbit Polyclonal S1PR2 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human S1PR2 aa 250 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human S1PR2 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.O95136

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purity >95%., Storage buffer-pH: 7.4Preservative: 0.03% Proclin 300Constituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
S1PR2 also known as Sphingosine-1-phosphate receptor 2 is a G protein-coupled receptor with a mass of approximately 38 kDa. This receptor plays a role in cell signaling by binding to its ligand sphingosine-1-phosphate (S1P) which leads to various intracellular responses. S1PR2 is expressed in various tissues including the brain heart and immune cells where it affects physiological processes like cell proliferation migration and vascular stability.
Biological function summary
The receptor S1PR2 modulates the immune system and vascular function. It does not work alone but interacts with other S1P receptors to regulate the immune response and vascular tone. In immune cells S1PR2 influences cell movement and adhesion impacting mechanisms such as lymphocyte trafficking and immune modulation.
Pathways
S1PR2 is an important part of the sphingosine-1-phosphate signaling pathway. This pathway affects vascular and immune functions by interacting with downstream signaling molecules like Rho and Rac. S1PR2 also connects with other S1P receptors like S1PR1 and S1PR3 forming a network that controls cell motility and vascular health.
S1PR2 has implications in conditions like cancer and multiple sclerosis. In cancer S1PR2 affects tumor growth and metastasis through signaling pathways that control cell migration and angiogenesis. Its interaction with proteins like RhoA may contribute to cancer progression. In multiple sclerosis S1PR2 influences immune cell infiltration in the central nervous system adding complexity to immune-related disease mechanisms.