Abcam, ab236074, Anti-Somatostatin Receptor 5 antibody [UMB4] - BSA and Azide free

Size: 100µg / 1mg
Rabbit Recombinant Monoclonal Somatostatin Receptor 5 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:UMB4,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Internal WB test in PANC-1, human pancreas and human brain lysates indicates this antibody might not detect endogenous Somatostatin Receptor 5.

Product details:
ab236074 is the carrier-free version of
ab109495
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies
Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.
Use our
conjugation kits
for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.
Compatibility
This product is compatible with the Maxpar
Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar
is a trademark of Fluidigm Canada Inc.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Somatostatin Receptor 5 also known as SSTR5 is a G protein-coupled receptor with a molecular weight of approximately 61 kDa. Mechanically SSTR5 couples with G proteins to inhibit adenylyl cyclase activity leading to reduced cAMP levels. This receptor is expressed in different tissues including the brain pituitary gland and pancreas reflecting its diverse physiological roles. SSTR5 exhibits a distinct expression pattern compared to other somatostatin receptors providing a unique contribution to tissue-specific functions.
Biological function summary
The Somatostatin Receptor 5 regulates hormone secretion and cell proliferation. SSTR5 is not a part of a larger protein complex but it interacts with molecules such as somatostatin which is a peptide hormone that inhibits the release of several other hormones. Through these interactions SSTR5 helps control endocrine and exocrine secretions. Its role in modulating cell growth makes it an important factor in maintaining tissue homeostasis and influencing cell signaling processes.
Pathways
Somatostatin Receptor 5 is involved in the cAMP signaling pathway and the MAPK/ERK pathway. In the cAMP signaling pathway SSTR5 helps mediate the inhibitory effects on adenylyl cyclase while in the MAPK/ERK pathway it influences cell proliferation and differentiation. Related proteins in these pathways include other somatostatin receptors like SSTR2 with which SSTR5 might share regulatory effects on inhibitory processes. These pathways highlight the receptor's role in integrating multiple signaling cascades affecting both cellular metabolism and growth.
Somatostatin Receptor 5 is associated with growth hormone-related disorders such as acromegaly and certain types of cancer like pancreatic cancer. In acromegaly SSTR5 alongside SSTR2 impacts the pathological overproduction of growth hormone due to its expression in pituitary adenomas. In pancreatic cancer an altered expression of SSTR5 can influence tumor progression due to its regulatory effects on cell proliferation pathways. Understanding SSTR5's interaction with these diseases helps in developing therapeutic strategies targeting its specific signaling functions.