Abcam, ab236378, Anti-CRLF3 antibody [OTI2H3]

Size: 100µL
Mouse Monoclonal CRLF3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CRLF3.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI2H3,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CRLF3.Q8IUI8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CRLF3 also known as Cytokine Receptor-Like Factor 3 is a protein that acts within the cytokine receptor family. This target is involved in transmitting signals through the cell membrane. CRLF3 has a mass of approximately 50 kDa. Expression of CRLF3 occurs in a variety of tissues indicating its widespread role in cellular communication. The receptor plays a role in cytokine signaling which influences immune responses and cellular growth processes.
Biological function summary
CRLF3 contributes significantly to immune system function and neurodevelopment. It participates in forming receptor complexes necessary for signal transduction impacting various physiological processes. Studies have shown that CRLF3 participates in neuroimmune pathways linking neural and immune system activities. Researchers often explore its mechanism alongside related receptors such as those in the interleukin receptor family to fully understand its broad biological impact.
Pathways
Cytokine signaling pathways prominently involve CRLF3. Particularly it is part of the JAK-STAT signaling pathway which is important for mediating responses to various cytokines and growth factors. CRLF3 interacts with other signaling proteins including JAK kinases and STAT transcription factors to relay signals from external stimuli to the cell's interior influencing gene expression and affecting cellular responses.
Scientists have recognized connections between CRLF3 and neurological disorders. Research indicates that altered CRLF3 function may contribute to diseases such as multiple sclerosis and epilepsy. Furthermore its interaction with proteins relevant to immune response and neural signaling suggests potential roles in these conditions. Understanding CRLF3's involvement in these disorders could offer valuable insights into possible therapeutic strategies.