Abcam, ab236386, Anti-GAS8 antibody [OTI10G2]

Size: 100µL
Mouse Monoclonal GAS8 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GAS8.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:OTI10G2,
Isotype:IgG1,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human GAS8.O95995

Product details:
Clone OTI10G2 (formerly 10G2).

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-Purified from cell culture supernatant., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein known as Growth arrest-specific protein 8 (GAS8) which is also referred to as GAS11 plays an important role in the mechanical stability and movement of intracellular structures. It has an approximate mass of 87 kDa. GAS8 is expressed in a range of tissues but shows high expression in ciliated structures such as in the respiratory tract and reproductive tissues. It operates mainly as a component of the microtubule organizing centers associating with various cytoskeletal elements.
Biological function summary
Within the framework of cell function GAS8 interacts with the axonemal dynein complex. This protein aids in regulating ciliary motion essential for proper cilia and flagella function. As a component of the axoneme a structural feature of cilia and flagella GAS8 contributes to microtubule network stability and arrangement. It also bridges interactions between microtubules and ciliary dynein thereby facilitating efficient movement.
Pathways
GAS8 exerts its functions predominantly in the dynein arm assembly pathway. This pathway is critical for axonemal dynein arm stabilization important for beating motion. GAS8 works in concert with proteins like dynein light chain and axonemal dynein heavy chain to form functional ciliary complexes. These pathways are vital for cell signaling and fluid movement across epithelial cells.
Impaired GAS8 function has connections to primary ciliary dyskinesia (PCD) and respiratory disorders. Abnormalities in GAS8 expression or mutation can result in defective cilia leading to respiratory illnesses and symptoms of PCD such as chronic bronchitis and sinusitis. The interaction between GAS8 and other axonemal proteins like dynein helps form a comprehensive understanding of their impact on hereditary ciliopathies and disorders.